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Oregon Health & Science University Postdoctoral Researcher in Portland, Oregon

This position will focus on NK cell resistance in acute myeloid leukemia. The work aims to identify additional receptor targets and to define mechanisms responsible for innate immune evasion. Our primary approach is to identify genes crucial for malignant cell viability and growth in leukemia cell lines and patients samples before and after small molecule inhibitor exposure. We utilize CRISPR/Cas9 library screens combined with deep sequencing of exposed cell lines and primary patient samples to identify functionally important signaling pathways required for leukemogenesis and resistance to targeted therapies.

This position will involve cell culture, use of AML cell lines and processing of primary patient samples for use in downstream analyses. One area of focus will be aiding with CRISPR/Cas 9 library screens to identify essential genes required for leukemogeneis and to identify compensatory pathway activation in the context of drug resistance. These experiments will be carried out with NK cells in primary leukemia samples as well as cell line models.

Some evening and weekend work may be required. General responsibilities include molecular techniques, mammalian tissue culture, drug co-culture, flow cytometry, and analysis of data.

PhD required

Required competencies:

  • Molecular biology techniques required: RNAi , PCR, primer design, cell culture, transfections, transductions, Western blots, cloning, sequencing.

  • In depth knowledge of specific areas of responsibility

  • Ability to operate complex scientific equipment

  • Passion for science and inquiry

  • Ability to synthesize one’s own results and others to formulate hypotheses

  • Ability to prioritize multiple tasks at one time

  • Must have excellent communication, analytical and organizational skills: both written and verbal.

  • Ability to work independently and as part of a team while being collaborative in resolving problems.

  • Ability to work with and supervise junior staff

  • Must be proficient with computers running Windows and PC applications e.g. MS Excel, Oracle, Access, Word and PowerPoint).

  • Must possess energy and drive to coordinate multiple projects simultaneously.

Ability to use tact and diplomacy to maintain effective working relationships

  • Must have demonstrated excellent customer service skills both on the phone and in person

  • PhD degree in science or technology

  • Graduate work in Molecular Biology

  • Laboratory experience, preferably in cellular and molecular biology

Apply online. Please be sure to submit a CV/resume and cover letter with your application.

Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or

Recruitment ID: 2020-6455

External Company URL: dturner

Street: Waterfront

Job Type: Postdoctoral

Posting Department: Knight Cancer Institute, Center for Hematologic Malignancies (CHM)

Posting Pay: $52,704 - $55,596, commensurate with NIH guidelines

Posting FTE: 1.00

Posting Schedule: Monday - Friday

Posting Hours: TBD

HR Mission: School of Medicine

Drug Testable: Yes